공과대학 - 공과대학

  • 부교수 Systems Biotechnology
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    Lab 공정설계 및 시스템공학 연구실

관심분야

- Systems biology/biotechnology/bioinformatics
- Process Digital Twins
- Microbiome engineering
- Drug & disease modeling and control
- Health/energy/environmental policy modeling

학술지 논문

  • (2024)  Kinetics-based inference of environment-dependent microbial interactions and their dynamic variation.  MSYSTEMS.  9,  4
  • (2024)  Driving towards digital biomanufacturing by CHO genome-scale models.  TRENDS IN BIOTECHNOLOGY.  42,  5
  • (2024)  Decoding cellular mechanism of recombinant adeno-associated virus (rAAV) and engineering host-cell factories toward intensified viral vector manufacturing.  BIOTECHNOLOGY ADVANCES.  71, 
  • (2024)  Evaluating oleaginous yeasts for enhanced microbial lipid production using sweetwater as a sustainable feedstock.  MICROBIAL CELL FACTORIES.  23, 
  • (2024)  Exploring metabolic effects of dipeptide feed media on CHO cell cultures by in silico model-guided flux analysis.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY.  108, 
  • (2023)  Data-driven prediction models for forecasting multi-step ahead profiles of mammalian cell culture towards bioprocess digital twins.  BIOTECHNOLOGY AND BIOENGINEERING.  120,  9
  • (2023)  Debottlenecking and reformulating feed media for improved CHO cell growth and titer by data-driven and model-guided analyses.  BIOTECHNOLOGY JOURNAL.  18, 
  • (2023)  Mitigating biomass composition uncertainties in flux balance analysis using ensemble representations.  COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL.  21,  -
  • (2023)  Genome-scale metabolic modeling and <i>in silico</i> analysis of opportunistic skin pathogen <i>Cutibacterium acnes</i>.  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY.  13,  -
  • (2023)  Enhanced cell growth, production, and mAb quality produced in Chinese hamster ovary-K1 cells by supplementing polyamine in the media.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY.  107,  9
  • (2023)  Liver's influence on the brain through the action of bile acids.  FRONTIERS IN NEUROSCIENCE.  17, 
  • (2022)  Systematic evaluation of genome-wide metabolic landscapes in lactic acid bacteria reveals diet- and strain-specific probiotic idiosyncrasies.  CELL REPORTS.  41,  10
  • (2022)  Data-driven and model-guided systematic framework for media development in CHO cell culture.  METABOLIC ENGINEERING.  73,  1
  • (2022)  Editorial: Heterologous Protein Expression and Production Platforms: The How, Now and Wow of It, Volume II.  FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY.  10, 
  • (2022)  Combined multivariate statistical and flux balance analyses uncover media bottlenecks to the growth and productivity of Chinese hamster ovary cell cultures.  BIOTECHNOLOGY AND BIOENGINEERING.  119,  7
  • (2022)  Systems Biology of Gut Microbiota-Human Receptor Interactions: Toward Anti-inflammatory Probiotics.  FRONTIERS IN MICROBIOLOGY.  13, 
  • (2021)  Editorial: Predictive Modeling of Human Microbiota and Their Role in Health and Disease.  FRONTIERS IN MICROBIOLOGY.  12,  1
  • (2021)  Multi-omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer, and product quality.  BIOTECHNOLOGY AND BIOENGINEERING.  118,  11
  • (2021)  Bioprocess digital twins of mammalian cell culture for advanced biomanufacturing.  CURRENT OPINION IN CHEMICAL ENGINEERING.  33, 
  • (2021)  Combination of red and blue light induces anthocyanin and other secondary metabolite biosynthesis pathways in an age-dependent manner in Batavia lettuce.  PLANT SCIENCE.  310, 

학술회의논문

  • (2022)  Characterizing basal and feed media effects on mammalian cell cultures by systems engineering approaches.  Part of special issue:13th IFAC Symposium on Dynamics and Control of Process Systems.  대한민국